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Z-VAD-FMK (CAS: 187389-52-2)
Catalog #£ºEBC51064
  SKU-Pack Size Availability Size Price
EBC51064-1ML In Stock 1mL(10mM in DMSO) €193.70 / €135.59
EBC51064-1MG In Stock 1mg €76.70 / €53.69
EBC51064-5MG In Stock 5mg €206.70 / €144.69
EBC51064-10MG In Stock 10mg €323.70 / €226.59
EBC51064-25MG In Stock 25mg €583.70 / €408.59
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Product Information
Synonym(s) Z-VAD(OMe)-FMK
Chemical Name methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate
Application Z-VAD-FMK is Irreversible, cell-permeable, broad-spectrum caspase Inhibitor
CAS Number 187389-52-2
Purity ¡Ý99.0%
Molecular Weight 467.49
Molecular Formula C₂₂H₃₀FN₃O₇
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
Target & IC50 caspase processing and apoptosis: IC50 = 0.0015 - 5.8 mM
Solubility DMSO : 100 mg/mL (213.91 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1391 ml 10.6954 ml 21.3908 ml
5 mM 0.4278 ml 2.1391 ml 4.2782 ml
10 mM 0.2139 ml 1.0695 ml 2.1391 ml
50 mM 0.0428 ml 0.2139 ml 0.4278 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor. Z-VAD-FMK limited Fas-induced mouse liver damage and apoptosis to <1% and abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells at 50 μM.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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