USA:(540) 808-3925
China:400-117-0038
United Kingdom
Shopping Cart
Sign in \ Register
OAC-1 (CAS: 300586-90-7)
Catalog #:EBC51146
  SKU-Pack Size Availability Size Price
EBC51146-1ML In Stock 1mL(10mM in DMSO) £75.90
EBC51146-2MG In Stock 2mg £53.90
EBC51146-10MG In Stock 10mg £108.90
EBC51146-50MG In Stock 50mg £361.90
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
CUlabSciences Phone:+44 (0) 1232 330008
Cambridge House St Thomas' Place Ely, E-mail:sales@culabsciences.co.uk
United Kingdom Cambridge CB27 9RD UK Web:www.culabsciences.co.uk
Product Information
Synonym(s) BAS 00287861, OAC1, AC1LG6VC
Chemical Name N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Application OAC1 is an activator of Oct4
CAS Number 300586-90-7
Purity ≥98.0%
Molecular Weight 237.26
Molecular Formula C₁₄H₁₁N₃O
SMILES C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3
Target & IC50 OCT4
Solubility DMSO: 23.7 mg/mL (100 mM)
Ethanol: 23.7 mg/mL (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.2148 ml 21.0739 ml 42.1479 ml
5 mM 0.8430 ml 4.2148 ml 8.4296 ml
10 mM 0.4215 ml 2.1074 ml 4.2148 ml
50 mM 0.0843 ml 0.4215 ml 0.8430 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. IC50 value: Target: Oct4 activator in vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved.  备案号:津ICP备2022005142号-1