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OAC-1 (CAS: 300586-90-7)
Catalog #£ºEBC51146
  SKU-Pack Size Availability Size Price
EBC51146-1ML In Stock 1mL(10mM in DMSO) €89.70
EBC51146-2MG In Stock 2mg €63.70
EBC51146-10MG In Stock 10mg €128.70
EBC51146-50MG In Stock 50mg €427.70
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Product Information
Synonym(s) BAS 00287861, OAC1, AC1LG6VC
Chemical Name N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Application OAC1 is an activator of Oct4
CAS Number 300586-90-7
Purity ¡Ý98.0%
Molecular Weight 237.26
Molecular Formula C₁₄H₁₁N₃O
SMILES C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3
Target & IC50 OCT4
Solubility DMSO: 23.7 mg/mL (100 mM)
Ethanol: 23.7 mg/mL (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.2148 ml 21.0739 ml 42.1479 ml
5 mM 0.8430 ml 4.2148 ml 8.4296 ml
10 mM 0.4215 ml 2.1074 ml 4.2148 ml
50 mM 0.0843 ml 0.4215 ml 0.8430 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. IC50 value: Target: Oct4 activator in vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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