Protein Agonists, Antagonists and Activators

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OAC-1 (CAS: 300586-90-7)

Catalog #：EBC51146

Datasheet

OAC-1 (CAS: 300586-90-7)

SKU-Pack Size	Availability	Size	Price
EBC51146-1ML	In Stock	1mL(10mM in DMSO)	￡75.90
EBC51146-2MG	In Stock	2mg	￡53.90
EBC51146-10MG	In Stock	10mg	￡108.90
EBC51146-50MG	In Stock	50mg	￡361.90

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Product Information

Synonym(s)

BAS 00287861, OAC1, AC1LG6VC

Chemical Name

N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Application

OAC1 is an activator of Oct4

CAS Number

300586-90-7

Purity

≥98.0%

Molecular Weight

237.26

Molecular Formula

C₁₄H₁₁N₃O

SMILES

C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3

Target & IC50

OCT4

Solubility

DMSO: 23.7 mg/mL (100 mM)
Ethanol: 23.7 mg/mL (100 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.2148 ml	21.0739 ml	42.1479 ml
5 mM	0.8430 ml	4.2148 ml	8.4296 ml
10 mM	0.4215 ml	2.1074 ml	4.2148 ml
50 mM	0.0843 ml	0.4215 ml	0.8430 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. IC50 value: Target: Oct4 activator in vitro: OAC1 enhances the formation of Oct4-GFP+ colonies and accelerates the dynamics of reprogramming. OAC1 enhanced reprogramming efficiency through a mechanism that is independent of endogenous Oct4 promoter demethylation. OAC1 enhanced reprogramming efficiency through a mechanism that is distinct from suppressing p53-p21 expression. Luciferase assay revealed that OAC1 had no effect on Topflash activity, although BIO activated the Topflash reporter potently. OAC1 functions through a mechanism that is independent of the Wnt signaling.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol