Protein Inhibitors - Z-VAD-FMK (CAS: 187389-52-2)

Z-VAD-FMK (CAS: 187389-52-2)

Catalog #：EBC51064

Z-VAD-FMK (CAS: 187389-52-2)

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Product Information

Synonym(s)

Z-VAD(OMe)-FMK

Chemical Name

methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate

Application

Z-VAD-FMK is Irreversible, cell-permeable, broad-spectrum caspase Inhibitor

CAS Number

187389-52-2

Purity

≥99.0%

Molecular Weight

467.49

Molecular Formula

C₂₂H₃₀FN₃O₇

SMILES

C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1

Target & IC50

caspase processing and apoptosis: IC50 = 0.0015 - 5.8 mM

Solubility

DMSO : 100 mg/mL (213.91 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor. Z-VAD-FMK limited Fas-induced mouse liver damage and apoptosis to <1% and abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells at 50 μM.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol