Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs)