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Salermide (CAS: 1105698-15-4)
Catalog #:EBC51025
  SKU-Pack Size Availability Size Price
EBC51025-1ML In Stock 1mL(10mM in DMSO) $103.50
EBC51025-2MG In Stock 2mg $73.50
EBC51025-5MG In Stock 5mg $103.50
EBC51025-10MG In Stock 10mg $148.50
EBC51025-25MG In Stock 25mg $298.50
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Product Information
Synonym(s) Salermide
Chemical Name N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide
Application Salermide is an inhibitor of SIRT1, SIRT2, and HDAC
CAS Number 1105698-15-4
Purity ≥99.0%
Molecular Weight 394.47
Molecular Formula C26H22N2O2
SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43
Target & IC50 SIRT2: IC50 = 25 μM (human)
SIRT1: IC50 = 40.3 μM (human)
Solubility DMSO: 78 mg/mL (197.73 mM)
Ethanol (warmed with 50oC water bath) 8 mg/mL (20.28 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5351 ml 12.6754 ml 25.3508 ml
5 mM 0.5070 ml 2.5351 ml 5.0702 ml
10 mM 0.2535 ml 1.2675 ml 2.5351 ml
50 mM 0.0507 ml 0.2535 ml 0.5070 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs)

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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