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BPI Rabbit Monoclonal Antibody
Catalog #:EAB21726
  SKU-Pack Size Availability Size Price
EAB21726-100UL In Stock 100ul $343.50
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Product Information
Applications WB, FC
Species Reactivity Human, Zebrafish
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:500-2000
FC=1:10-100
MW (kDa) 54
Conjugate Unconjugate
Specificity BPI Rabbit Monoclonal Antibody detects endogenous levels of BPI protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) BPIFD1; rBPI; Bactericidal permeability-increasing protein; Bactericidal/permeability increasing protein; BPI; CAP57
Gene Aliases BPI
UniProt ID

P17213

Entrez Gene ID

671

Product Description

The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. The binding of BPI to lipid A causes multiple anti-infective activities against gram-negative bacteria. These include: cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, neutralization of gram-negative bacterial LPS, opsonization of bacteria to enhance phagocytosis by neutrophils. BPI may be a critical determinant in the development of LPStriggered airways disease since airway epithelial cells constitutively express the BPI gene and produce the BPI protein. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.

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Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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