USA:(540) 808-3925
China:400-117-0038
China
Shopping Cart
Sign in \ Register
Acetyl-p53 (Lys120) Rabbit Polyclonal Antibody
Catalog #:EAB14480
  SKU-Pack Size Availability Size Price
EAB14480-30UL In Stock 30ul ¥1090.00
EAB14480-100UL In Stock 100ul ¥2290.00
EAB14480-200UL In Stock 200ul ¥3690.00
If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com
Please select the country you are in to find your local distributor.
北京美瑞克生物科技有限公司 Phone:  +86 010-62890160 / 13691184142(微信同号)
2 / F, 128 malianwa North Road, Haidian District, E-mail:   mrkbio@163.com 
China Beijing China Website: www.mrkbio.com
Product Information
Applications WB, ELISA
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000
MW (kDa) 44
Conjugate Unconjugate
Specificity Acetyl-p53 (Lys120) Rabbit Polyclonal Antibody detects endogenous levels of p53 protein only when acetylated at Lys120.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) bbl; BCC7; bfy; bhy; LFS1; p44; P53; TP53; TRP53
Gene Aliases TP53
UniProt ID

P04637

Entrez Gene ID

7157

Product Description

p53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor. The p53 protein upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. The p53 Antibody can stain both the nucleus and cytoplasm, as the p53 protein localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. phospho-specific p53 Antibodies can differentiate between phosphorylated and non-phosphorylated p53. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers. p53 Antibody is therefore an important reagent for cancer research. 

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved.  备案号:津ICP备2022005142号-1