USA£º(540) 808-3925
China£º400-117-0038
Germany
Shopping Cart
Sign in \ Register
LDN 193189 (CAS: 1062368-24-4)
Catalog #£ºEBC51133
  SKU-Pack Size Availability Size Price
EBC51133-1MG In Stock 1mg €76.70
EBC51133-5MG In Stock 5mg €102.70
EBC51133-10MG In Stock 10mg €167.70
EBC51133-25MG In Stock 25mg €310.70
EBC51133-50MG In Stock 50mg €518.70
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
Dianost Phone£º+49 (0) 40 65472-053
Bullenkoppel 11£¬ 23896 Poggensee, E-mail£ºola@olasciences.com
Germany Germany Web£ºwww.olasciences.com
Product Information
Synonym(s) LDN 193189, LDN-193189, DM-3189
Chemical Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Application LDN193189 is a selective transcriptional activity morphogenetic protein (BMP) type I receptors inhibitor
CAS Number 1062368-24-4
Purity ¡Ý98.0%
Molecular Weight 406.48
Molecular Formula C₂₅H₂₂N₆
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
Target & IC50 ALK2: IC50 = 5 nM
ALK3: IC50 = 30 nM
Solubility DMSO : 12 mg/mL (29.52 mM; ultrasonic and adjust pH to 2 with HCl)
Ethanol : 1 mg/mL (2.46 mM; Need ultrasonic)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.4601 ml 12.3007 ml 24.6015 ml
5 mM 0.4920 ml 2.4601 ml 4.9203 ml
10 mM 0.2460 ml 1.2301 ml 2.4602 ml
50 mM 0.0492 ml 0.2460 ml 0.4920 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

LDN 193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC₅₀≥ 500 nM). It inhibits the activation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 in a dose-dependent manner in C2C12 cells. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved. ¡¡±¸°¸ºÅ£º½òICP±¸2022005142ºÅ-1