Other Biochemicals - (Z)-4-Hydroxytamoxifen (CAS: 68047-06-3)

(Z)-4-Hydroxytamoxifen (CAS: 68047-06-3)

Catalog #：EBC51048

(Z)-4-Hydroxytamoxifen
(CAS: 68047-06-3)

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Product Information

Synonym(s)

4-Hydroxytamoxifen, trans-4-Hydroxytamoxifen

Chemical Name

4-[(Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

Application

(Z)-4-Hydroxytamoxifen is an active metabolite of the antineoplastic agent Tamoxifen and an anti-estrogen agent

CAS Number

68047-06-3

Purity

≥99.0%

Molecular Weight

387.51

Molecular Formula

C₂₆H₂₉NO₂

SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3.[(Z)]

Target & IC50

MCF7 : IC50 = 0.5 nM (human)
Estrogen receptor beta: IC50 = 0.5 nM (human)

Solubility

DMSO: 28 mg/mL (72.26 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
(Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol