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Pleconarilis (CAS: 153168-05-9)
Catalog #:EBC51033
  SKU-Pack Size Availability Size Price
EBC51033-1ML In Stock 1mL(10mM in DMSO) ¥990.00
EBC51033-2MG In Stock 2mg ¥590.00
EBC51033-5MG In Stock 5mg ¥890.00
EBC51033-10MG In Stock 10mg ¥1390.00
EBC51033-25MG In Stock 25mg ¥2290.00
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Product Information
Synonym(s) Win 63843, VP 63843, APO-P001, Picovir
Chemical Name 3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
Application Pleconaril is a capsid inhibitor used previously to treat enterovirus infections
CAS Number 153168-05-9
Purity ≥99.85%
Molecular Weight 381.35
Molecular Formula C₁₈H₁₈F₃N₃O₃
SMILES FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F
Target & IC50 Capsid: IC50 = 50 nM
Solubility DMSO: 76 mg/mL (199.29 mM)
Ethanol: 76 mg/mL (199.29 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.6223 ml 13.1113 ml 26.2226 ml
5 mM 0.5245 ml 2.6223 ml 5.2445 ml
10 mM 0.2622 ml 1.3111 ml 2.6223 ml
50 mM 0.0524 ml 0.2622 ml 0.5245 ml
Shipping Room Temperature
Storage Room Temperature
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Pleconaril is an antiviral drug potentially for the treatment of enterovirus infection and asthma. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.It has shown useful activity against the dangerous strain enterovirus D68. Pleconaril binds to a hydrophobic pocket in the VP1 protein. Pleconaril has been shown in viral assembly to associate with viral particles.[9] Through noncovalent, hydrophobic interactions compounds can bind to the hydrophobic pocket. Amino acids in positions Tyr152 and Val191 are a part of the VP1 drug binding pocket. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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