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Avitinib maleate (CAS: 1557268-88-8)
Catalog #:EBC51029
  SKU-Pack Size Availability Size Price
EBC51029-1ML In Stock 1mL(10mM in DMSO) $223.50
EBC51029-5MG In Stock 5mg $103.50
EBC51029-10MG In Stock 10mg $163.50
EBC51029-50MG In Stock 50mg $598.50
EBC51029100MG In Stock 100mg $913.50
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Product Information
Synonym(s) AC0010MA, AC-0010MA, AC 0010MA, AC0010, AC-0010, AC 0010
Chemical Name N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
Application Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
CAS Number 1557268-88-8
Purity ≥99.0%
Molecular Weight 603.61
Molecular Formula C₃₀H₃₀FN₇O₆
SMILES CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F.C(=C\C(=O)O)\C(=O)O
Target & IC50 EGFR
Solubility DMSO: 300 mg/mL (497.02 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.6567 ml 8.2835 ml 16.5670 ml
5 mM 0.3313 ml 1.6567 ml 3.3134 ml
10 mM 0.1657 ml 0.8284 ml 1.6567 ml
50 mM 0.0331 ml 0.1657 ml 0.3313 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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