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(+)-BAY-K-8644 (CAS: 98791-67-4)
Catalog #:EBC51007
  SKU-Pack Size Availability Size Price
EBC51007-1ML In Stock 1mL(10mM in DMSO) £141.90
EBC51007-5MG In Stock 5mg £163.90
EBC51007-10MG In Stock 10mg £218.90
EBC51007-25MG In Stock 25mg £493.90
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Product Information
Synonym(s) (R)-(+)-BAY K 8644, CHEMBL105672, (R)-(+)-Bay K8644
Chemical Name (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Application (R)-(+)-Bay K 8644 is an L-type calcium channel protein blocker
CAS Number 98791-67-4
Purity ≥99%
Molecular Weight 356.30
Molecular Formula C₁₆H₁₅F₃N₂O₄
SMILES CC1=C([N+]([O-])=O)[C@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1
Target & IC50 Ba2+ currents (IBa): IC50 = 975 nM
Solubility DMSO: 300 mg/mL (841.99 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.8066 ml 14.0331 ml 28.0662 ml
5 mM 0.5613 ml 2.8066 ml 5.6132 ml
10 mM 0.2807 ml 1.4033 ml 2.8066 ml
50 mM 0.0561 ml 0.2807 ml 0.5613 ml
Shipping Gel Pack
Storage Store at -20° C
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Product Description

(R)-(+)-Bay K 8644 is a L-type calcium channel protein blocker with negative inotropic effects. (R)-(+)-Bay K 8644 is an enantiomer showing opposite effects to the racemate (±)-Bay K 8644 and and (S)-(−)-Bay K8644. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (+)-BAY-K-8644.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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