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Pluripotin (CAS: 839707-37-8)
Catalog #:EBC51150
  SKU-Pack Size Availability Size Price
EBC51150-1ML In Stock 1mL(10mM in DMSO) $208.50
EBC51150-2MG In Stock 2mg $118.50
EBC51150-5MG In Stock 5mg $148.50
EBC51150-10MG In Stock 10mg $223.50
EBC51150-25MG In Stock 25mg $448.50
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Product Information
Synonym(s) SC1, SC 1, SC-1
Chemical Name N-(3-(7-(1,3-Dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Application Pluripotin is a dual inhibitor of ERK1 and RasGAP
CAS Number 839707-37-8
Purity ≥99.0%
Molecular Weight 550.54
Molecular Formula C₂₇H₂₅F₃N₈O₂
SMILES CN1C(NC2=NC=C3C(N(C)C(N(C4=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=CC=C4C)C3)=O)=N2)=CC(C)=N1
Target & IC50 RSK1: IC50 = 0.5 μM
RSK2: IC50 = 2.5 μM
RSK3: IC50 = 3.3 μM
RSK3: IC50 = 10 μM
Solubility DMSO : 100 mg/mL (181.64 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.8164 ml 9.0822 ml 18.1643 ml
5 mM 0.3633 ml 1.8164 ml 3.6329 ml
10 mM 0.1816 ml 0.9082 ml 1.8164 ml
50 mM 0.0363 ml 0.1816 ml 0.3633 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Pluripotin is a small molecule shown to sustain self-renewal of mouse embryonic stem (mES) cells. In order to maintain embryonic stem cells in an undifferentiated state, it is typically necessary to use a combination of feeder cells, leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP); Pluripotin allows for stem cell propagation in the absence of these factors. The activity of Pluripotin is mediated by Ras signaling which promotes self-renewal, and inhibition of ERK blocks differentiation.

 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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