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PD 98059 (CAS: 167869-21-8)
Catalog #£ºEBC51148
  SKU-Pack Size Availability Size Price
EBC51148-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51148-5MG In Stock 5mg €63.70
EBC51148-10MG In Stock 10mg €89.70
EBC51148-50MG In Stock 50mg €141.70
EBC51148-100MG In Stock 100mg €245.70
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Product Information
Synonym(s) PD-98059, PD98059
Chemical Name 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Application PD 98059 is a selective and reversible inhibitor of MAPK-activating enzyme
CAS Number 167869-21-8
Purity ¡Ý99.0%
Molecular Weight 267.28
Molecular Formula C₁₆H₁₃NO₃
SMILES O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N
Target & IC50 MEK1: IC50 = 4 ¦ÌM
MEK2: IC50 = 50 ¦ÌM
Solubility DMSO: 46 mg/mL (172.10 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.7414 ml 18.7070 ml 37.4139 ml
5 mM 0.7483 ml 3.7414 ml 7.4828 ml
10 mM 0.3741 ml 1.8707 ml 3.7414 ml
50 mM 0.0748 ml 0.3741 ml 0.7483 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 μM) produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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