USA£º(540) 808-3925
China£º400-117-0038
Spain
Shopping Cart
Sign in \ Register
Nicotinamide (CAS: 98-92-0)
Catalog #£ºEBC51143
  SKU-Pack Size Availability Size Price
EBC51143-1ML In Stock 1mL(10mM in DMSO) €89.70
EBC51143-500MG In Stock 500mg €63.70
EBC51143-1G In Stock 1g €89.70
EBC51143-5G In Stock 5g €128.70
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
Betaclonal Phone£º+34 (0)91 471 6763
29/1 Lomonosovsky Pr, E-mail£ºtech@betaclonal.com
Spain Madrid, Spain Web£ºwww.betaclonal.com
Product Information
Synonym(s) Niacinamide, Nicotinic acid amide, Vitamin B3
Chemical Name pyridine-3-carboxamide
Application Nicotinamide is an NAD+ and NADP+ coenzyme precursor
CAS Number 98-92-0
Purity ¡Ý98.0%
Molecular Weight 122.1
Molecular Formula C₆H₆N₂O
SMILES C1=CC(=CN=C1)C(=O)N
Target & IC50 Anandamide amidohydrolase: IC50 = 3.3 ¦ÌM
NAD-dependent deacetylase sirtuin 2: IC50 = 11 ¦ÌM
Solubility DMSO: 22 mg/mL (180.2 mM)
Ethanol: 22 mg/mL (180.2 mM)
Water: 22 mg/mL (180.2 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 8.1887 ml 40.9433 ml 81.8867 ml
5 mM 1.6377 ml 8.1887 ml 16.3773 ml
10 mM 0.8189 ml 4.0943 ml 8.1887 ml
50 mM 0.1638 ml 0.8189 ml 1.6377 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Nicotinamide is an inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is found as a DNA repair enzyme. The excessive activation of PARP-1, such as ischemia and trauma, can deplete cellular nicotinamide adenine dinucleotide as a substrate and leads to brain cell death eventually.

In vitro: Previous findings suggested that nicotinamide had a protective effect against PARP-1-induced astrocyte death. The transporter-mediated uptake of nicotinamide, which was extracellular pH-sensitive and common to N-methylnicotinamide, was found to be critical for prevention of PARP-1-triggered cell death.

In vivo: Type 2 diabetes was induced in Wistar rats by streptozotocin followed by nicotinamide. Test compounds and standard treatment were continued for 15 days. Results showed that there was significant normalisation of liver antioxidant enzymes compared to diabetic rats, suggesting all the tested compounds were beneficial in reducing oxidative stress. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved. ¡¡±¸°¸ºÅ£º½òICP±¸2022005142ºÅ-1