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LY 411575 (CAS: 209984-57-6)
Catalog #£ºEBC51139
  SKU-Pack Size Availability Size Price
EBC51139-1ML In Stock 1mL(10mM in DMSO) €141.70
EBC51139-5MG In Stock 5mg €128.70
EBC51139-10MG In Stock 10mg €167.70
EBC51139-25MG In Stock 25mg €336.70
EBC51139-50MG In Stock 50mg €518.70
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Product Information
Synonym(s) LY-411575, LY411575
Chemical Name (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
Application LY411575 is a potent ¦Ã-secretase inhibitor
CAS Number 209984-57-6
Purity ¡Ý98.0%
Molecular Weight 479.48
Molecular Formula C₂₆H₂₃F₂N₃O₄
SMILES C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
Target & IC50 ¦Ã-secretase IC50: = 0.078 nM
Solubility DMSO: 88 mg/mL (183.5 mM)
Ethanol: 11 mg/mL (22.9 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.0856 ml 10.4280 ml 20.8559 ml
5 mM 0.4171 ml 2.0856 ml 4.1712 ml
10 mM 0.2086 ml 1.0428 ml 2.0856 ml
50 mM 0.0417 ml 0.2086 ml 0.4171 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

γ-Secertase is one of intramenbrane-cleaving aspartyl protease which cleaves many type-I membrane proteins and many of them have important biological functions. γ-Secretase is a multi-subunit protease and it contains presenilin, nicastrin, APH-1(Anterior Pharynx- defective 1) and PEN-2. Presenilin contains Asp258 and Asp385 embedded in the sixth and seventh transmembrane domain and forms the active site. The feature of being a membrane integrated protease complex makes it difficult to be purified as well as studying its mechanism.γ-secretase is responsible for the generation Aβfrom the amyloid precursor protein.γ-Secertase has been considered as an important drug target for Alzheimer's disease.γ-Secertase also is responsible for Notch processing which is related to cancer such as leukemia. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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