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LY 364947 (CAS: 396129-53-6)
Catalog #£ºEBC51138
  SKU-Pack Size Availability Size Price
EBC51138-1ML In Stock 1mL(10mM in DMSO) €102.70
EBC51138-5MG In Stock 5mg €76.70
EBC51138-10MG In Stock 10mg €115.70
EBC51138-25MG In Stock 25mg €219.70
EBC51138-50MG In Stock 50mg €349.70
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Product Information
Synonym(s) HTS466284, TbetaR-I Inhibitor
Chemical Name 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline
Application LY 364947 is a selective ATP-competitive inhibitor of TGF-¦Â Receptor I kinase
CAS Number 396129-53-6
Purity ¡Ý98.0%
Molecular Weight 272.31
Molecular Formula C₁₇H₁₂N₄
SMILES N1C=C(C(=N1)C1=NC=CC=C1)C1=CC=NC2=C1C=CC=C2
Target & IC50 TGF-¦Â Receptor I kinase : IC50 = 51 nM
RIPK2: IC50 = 0.11 ¦ÌM
Solubility DMSO: 27.2 mg/mL (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.6724 ml 18.3621 ml 36.7242 ml
5 mM 0.7345 ml 3.6724 ml 7.3448 ml
10 mM 0.3672 ml 1.8362 ml 3.6724 ml
50 mM 0.0734 ml 0.3672 ml 0.7345 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

LY 364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase). Studies of mouse fibroblasts show that LY 364947 inhibits cellular growth and transcription activation via TGF-β Receptor I kinase inhibition. In addition, TGF-β Receptor I kinase is responsible for fibroblast proliferation and the accumulation of astrocytes around the fibrotic scar when injury occurs to cells. In vitro studies report that in the presence of LY 364947 the amount of reactive astrocytes at the lesion site is also reduced. Furthermore, studies show that LY 364947 strongly effects intraplug vasculature by increasing the extravasation of Dextran (sc-218165). LY 364947 is an inhibitor of eIF2 alpha, MLTK, p38 alpha and TGF β RII. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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