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IWP-4 (CAS: 686772-17-8)
Catalog #:EBC51122
  SKU-Pack Size Availability Size Price
EBC51122-1ML In Stock 1mL(10mM in DMSO) $283.50
EBC51122-1MG In Stock 1mg $88.50
EBC51122-5MG In Stock 5mg $208.50
EBC51122-10MG In Stock 10mg $298.50
EBC51122-25MG In Stock 25mg $598.50
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Product Information
Synonym(s) Inhibitor of Wnt Production-4, IWP 4, IWP4
Chemical Name N-(6-Methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4- oxothieno[3,2-d]pyrimidin-2-yl]thio]acetamide
Application IWP-4 is a Wnt pathway inhibitor
CAS Number 686772-17-8
Purity ≥98.0%
Molecular Weight 496.62
Molecular Formula C₂₃H₂₀N₄O₃S₃
SMILES O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O
Target & IC50 Wnt: IC50 = 25 nM
Solubility DMSO: 2 mg/ml
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.0136 ml 10.0680 ml 20.1359 ml
5 mM 0.4027 ml 2.0136 ml 4.0272 ml
10 mM 0.2014 ml 1.0068 ml 2.0136 ml
50 mM 0.0403 ml 0.2014 ml 0.4027 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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