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IWP-2 (CAS: 686770-61-6)
Catalog #:EBC51120
  SKU-Pack Size Availability Size Price
EBC51120-1ML In Stock 1mL(10mM in DMSO) £64.90
EBC51120-5MG In Stock 5mg £53.90
EBC51120-10MG In Stock 10mg £75.90
EBC51120-25MG In Stock 25mg £152.90
EBC51120-50MG In Stock 50mg £262.90
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Product Information
Synonym(s) IWP 2, IWP2
Chemical Name N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3- phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Application IWP-2 is an inhibitor of Wnt production
CAS Number 686770-61-6
Purity ≥99.0%
Molecular Weight 466.60
Molecular Formula C₂₂H₁₈N₄O₂S₃
SMILES CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
Target & IC50 Wnt: IC50 = 27 nM
CK1δ: IC50 = 40 nM
Solubility DMSO : 2 mg/mL (4.29 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1432 ml 10.7158 ml 21.4316 ml
5 mM 0.4286 ml 2.1432 ml 4.2863 ml
10 mM 0.2143 ml 1.0716 ml 2.1432 ml
50 mM 0.0429 ml 0.2143 ml 0.4286 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

IWP-2 is an inactivator of Porcn function, and inhibitor of Wnt production. The Wnt/b-catenin (′canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to the disease stage. IWP-2 inhibits Wnt production. It appears that IWP-2 inactivates Porcn function either by modulating the function of a Porcn regulator or by directly inhibiting the Porcn active site. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 has been used to suppress embryonic stem cell self-renewal. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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