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ID-8 (CAS: 147591-46-6)
Catalog #:EBC51109
  SKU-Pack Size Availability Size Price
EBC51109-1ML In Stock 1mL(10mM in DMSO) £53.90
EBC51109-5MG In Stock 5mg £64.90
EBC51109-10MG In Stock 10mg £75.90
EBC51109-25MG In Stock 25mg £141.90
EBC51109-50MG In Stock 50mg £240.90
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Product Information
Synonym(s) HY-15838, ID8, DYRK inhibitor
Chemical Name 1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
Application ID-8 is an inhibitor of DYRK
CAS Number 147591-46-6
Purity ≥98.0%
Molecular Weight 298.29
Molecular Formula C₁₆H₁₄N₂O₄
SMILES OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3
Target & IC50 DYRK
Solubility DMSO: 29.8 mg/mL (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.3524 ml 16.7622 ml 33.5244 ml
5 mM 0.6705 ml 3.3524 ml 6.7049 ml
10 mM 0.3352 ml 1.6762 ml 3.3524 ml
50 mM 0.0670 ml 0.3352 ml 0.6705 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

ID-8 is a small molecule DYRK inhibitor. In HES2 cells, ID-8 (0.5 μM) increased hESC survival by 1.1%. The combination of ID-8 and Wnt3a increased survival by 1.7% and completely inhibited Wnt-induced morphological differentiation. Also, ID-8 significantly reduced the expression of differentiation marker gene GATA6, GSC, SOX17 and CDX2 induced by Wnt. In hESCs, ID-8 increased Wnt-mediated hESC proliferation and survival via inhibition of DYRKs. Also, DYRK family is direct targets of ID-8. In embryonic stem cells (ESCs), ID-8 (10 μM) stimulated proliferation in culture without MEFs, serum or LIF. The ID-8 induced ESCs showed the ability to form all three germ layer-derived tissues, such as liver, neurons and muscles. Also, ID-8 increased ESC differentiation and the levels of Nanog, Sox2 and Rex-1 . In mouse ESCs cultured in serum-free medium, ID-8 maintained their self-renewal and pluripotency.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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