Protein Inhibitors - Dorsomorphin (CAS: 866405-64-3)

Dorsomorphin (CAS: 866405-64-3)

Catalog #：EBC51090

Dorsomorphin (CAS: 866405-64-3)

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Product Information

Synonym(s)

Compound C, AMPK Inhibitor, BML-275

Chemical Name

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine

Application

Dorsomorphin is an effective and specific inhibitor of AMPK

CAS Number

866405-64-3

Purity

≥99.0%

Molecular Weight

399.49

Molecular Formula

C₂₄H₂₅N₅O

SMILES

C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Target & IC50

KDR/VEGFR2: IC50 = 25.1 nM
ALK2/BMPR-I: IC50 = 148 nM
AMPK kinase: IC50 = 234.6 nM

Solubility

DMSO： 3 mg/mL (7.51 mM)
Ethanol： 2 mg/mL (5.01 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol