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CHIR-99021 (CAS: 252917-06-9)
Catalog #:EBC51076
  SKU-Pack Size Availability Size Price
EBC51076-1ML In Stock 1mL(10mM in DMSO) $178.50
EBC51076-2MG In Stock 2mg $103.50
EBC51076-5MG In Stock 5mg $148.50
EBC51076-10MG In Stock 10mg $238.50
EBC51076-25MG In Stock 25mg $433.50
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Product Information
Synonym(s) GSK-3 Inhibitor XVI
Chemical Name 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Application CHIR-99021 is a GSK-3α/β inhibitor
CAS Number 252917-06-9
Purity ≥99.0%
Molecular Weight 465.34
Molecular Formula C₂₂H₁₈Cl₂N₈
SMILES N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2
Target & IC50 GSK-3α: IC50 = 10 nM
GSK-3β: IC50 = 6.7 nM
Solubility DMSO: 78 mg/mL (167.62 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1490 ml 10.7448 ml 21.4897 ml
5 mM 0.4298 ml 2.1490 ml 4.2979 ml
10 mM 0.2149 ml 1.0745 ml 2.1490 ml
50 mM 0.0430 ml 0.2149 ml 0.4298 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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