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Doxorubicin hydrochloride (CAS: 25316-40-9)
Catalog #£ºEBC51063
  SKU-Pack Size Availability Size Price
EBC51063-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51063-10MG In Stock 10mg €50.70
EBC51063-50MG In Stock 50mg €102.70
EBC51063-100MG In Stock 100mg €167.70
EBC51063-250MG In Stock 250mg €258.70
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Product Information
Synonym(s) NSC 123127, DOX, Hydroxydaunorubicin HCl, Topoisomerase II inhibitor
Chemical Name (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
Application Doxorubicin hydrochloride is an anthracycline antitumor antibiotic topoisomerase II inhibitor, DNA intercalator and powerful cytotoxic agent
CAS Number 25316-40-9
Purity ¡Ý99.0%
Molecular Weight 579.98
Molecular Formula C₂₇H₃₀ClNO₁₁
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
Target & IC50 Topoisomerase I : IC50 = 0.8 ¦ÌM
Topoisomerase II : IC50 = 2.67 ¦ÌM
Solubility DMSO : 35.71 mg/mL (61.57 mM)
H2O : 20 mg/mL (34.48 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.7242 ml 8.6210 ml 17.2420 ml
5 mM 0.3448 ml 1.7242 ml 3.4484 ml
10 mM 0.1724 ml 0.8621 ml 1.7242 ml
50 mM 0.0345 ml 0.1724 ml 0.3448 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once Doxorubicin hydrochloride associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives Doxorubicin hydrochloride efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin hydrochloride. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. Doxorubicin hydrochloride is also known as Hydroxydaunorubicin Hydrochloride, DOX, and (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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