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XAV939 (CAS: 284028-89-3)
Catalog #£ºEBC51062
  SKU-Pack Size Availability Size Price
EBC51062-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51062-5MG In Stock 5mg €50.70
EBC51062-10MG In Stock 10mg €76.70
EBC51062-25MG In Stock 25mg €141.70
EBC51062-50MG In Stock 50mg €232.70
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Product Information
Synonym(s) Tankyrase inhibitor, XAV 939, XAV-939, NVP-XAV939
Chemical Name 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
Application XAV939 is a potent inhibitor of beta-catenin, TNKS1, and TNKS2
CAS Number 284028-89-3
Purity ¡Ý98.5%
Molecular Weight 312.31
Molecular Formula C₁₄H₁₁F₃N₂OS
SMILES OC1=NC(C2=CC=C(C(F)(F)F)C=C2)=NC3=C1CSCC3
Target & IC50 Tankyrase 1: IC50 = 11 nM
Tankyrase 2: IC50 = 4 nM
Protein Wnt-3a: IC50 = 51 nM
Catenin beta-1: IC50 = 51 nM (human)
Solubility DMSO: 12 mg/mL (38.42 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.2019 ml 16.0097 ml 32.0195 ml
5 mM 0.6404 ml 3.2019 ml 6.4039 ml
10 mM 0.3202 ml 1.6010 ml 3.2020 ml
50 mM 0.0640 ml 0.3202 ml 0.6404 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

XAV939 is a potent, small molecule inhibitor of tankyrase 1 (TNKS) (IC50 = 11 nM) and tankyrase 2 (IC50 = 4 nM). By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.3 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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