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5-Azacytidine (CAS: 320-67-2)
Catalog #:EBC51058
  SKU-Pack Size Availability Size Price
EBC51058-1ML In Stock 1mL(10mM in DMSO) £53.90
EBC51058-100MG In Stock 100mg £42.90
EBC51058-200MG In Stock 250mg £64.90
EBC51058-500MG In Stock 500mg £130.90
EBC51058-1G In Stock 1g £185.90
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Product Information
Synonym(s) Ladakamycin, NSC 102816, Vidaza
Chemical Name 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Application 5-Azacytidine is a potent growth and Dnmt inhibitor
CAS Number 320-67-2
Purity ≥99.0%
Molecular Weight 244.20
Molecular Formula C₈H₁₂N₄O₅
SMILES NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@H](O)C1O
Target & IC50 DNMT1: IC50 = 0.2 μM
Solubility DMSO: 48 mg/mL (196.56 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.0948 ml 20.4742 ml 40.9484 ml
5 mM 0.8190 ml 4.0948 ml 8.1897 ml
10 mM 0.4095 ml 2.0474 ml 4.0948 ml
50 mM 0.0819 ml 0.4095 ml 0.8190 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively]. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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