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3-Deazaneplanocin A (CAS: 102052-95-9)
Catalog #:EBC51051
  SKU-Pack Size Availability Size Price
EBC51051-1MG In Stock 1mg £295.90
EBC51051-5MG In Stock 5mg £768.90
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Product Information
Synonym(s) DZNep, NSC 617989
Chemical Name (1S,2R,5R)-5-(4-Aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Application 3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27
CAS Number 102052-95-9
Purity ≥98.0%
Molecular Weight 262.3
Molecular Formula C₁₂H₁₄N₄O₃
SMILES O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N
Target & IC50 EZH2
Solubility DMSO: 20 mg/ml
DMF: 30 mg/ml
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.8129 ml 19.0643 ml 38.1286 ml
5 mM 0.7626 ml 3.8129 ml 7.6257 ml
10 mM 0.3813 ml 1.9064 ml 3.8129 ml
50 mM 0.0763 ml 0.3813 ml 0.7626 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

3-Deazaneplanocin is a highly potent inhibitor of S-adenosylhomocysteine hydrolase with Ki value of 0.05 nM. 3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27. The mechanism for this action is the inhibition of lysine methyltransferases, especially EZH2. It is reported to induce apoptosis in cancer cells to the exclusion of normal cells and useful in the generation of chemically induced pluripotent stem cells (CiPSCs).

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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