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AG 126 (CAS: 118409-62-4)
Catalog #£ºEBC51047
  SKU-Pack Size Availability Size Price
EBC51047-1ML In Stock 1mL(10mM in DMSO) €115.70 / €80.99
EBC51047-5MG In Stock 5mg €89.70 / €62.79
EBC51047-10MG In Stock 10mg €154.70 / €108.29
EBC51047-25MG In Stock 25mg €323.70 / €226.59
EBC51047-50MG In Stock 50mg €557.70 / €390.39
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Product Information
Synonym(s) Tyrphostin AG126
Chemical Name 2-[(3-Hydroxy-4-nitrophenyl)methylidene]propanedinitrile
Application AG 126 is selectively inhibits phosphorylation of ERK 1 and ERK 2
CAS Number 118409-62-4
Purity ¡Ý98.70%
Molecular Weight 215.17
Molecular Formula C₁₀H₅N₃O₃
SMILES C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
Target & IC50 epidermal GFRK: IC50 = 450 M
Solubility DMSO: 43 mg/mL (199.85 mM)
Ethanol: 2 mg/mL (9.30 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.6475 ml 23.2374 ml 46.4749 ml
5 mM 0.9295 ml 4.6475 ml 9.2950 ml
10 mM 0.4648 ml 2.3237 ml 4.6475 ml
50 mM 0.0930 ml 0.4647 ml 0.9295 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC50 = 15.38 μM).

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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