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NS-398 (CAS: 123653-11-2)
Catalog #:EBC51045
  SKU-Pack Size Availability Size Price
EBC51045-1ML In Stock 1mL(10mM in DMSO) $88.50
EBC51045-5MG In Stock 5mg $73.50
EBC51045-10MG In Stock 10mg $103.50
EBC51037-25MG In Stock 25mg $193.50
EBC51045-50MG In Stock 50mg $313.50
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Product Information
Synonym(s) NS 398, NS398
Chemical Name N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
Application NS-398 is a selective Cox-2 inhibitor neuroprotective agent
CAS Number 123653-11-2
Purity ≥99.0%
Molecular Weight 314.36
Molecular Formula C₁₃H₁₈N₂O₅S
SMILES CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2CCCCC2)=O
Target & IC50 COX-1: IC50 = 75 μM
COX-2: IC50 = 1.77 μM
Solubility DMSO: 62 mg/mL (197.23 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.1811 ml 15.9053 ml 31.8107 ml
5 mM 0.6362 ml 3.1811 ml 6.3621 ml
10 mM 0.3181 ml 1.5905 ml 3.1811 ml
50 mM 0.0636 ml 0.3181 ml 0.6362 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

NS-398 is a small molecule inhibitor of Cox (cyclooxygenase), relatively selective for Cox-2 (IC50 of 3.8 μM) over Cox-1 (IC50 of > 100 μM). The inflammatory response to injury and stimulus is associated with Cox-2 activity, and this activity is thought to be related to neurotoxicity presented in the progression of cerebral ischemia. NS-398 intervenes upon this progression through inhibition of Cox-2, potentially by suppressing the synthesis of Cox-2 reaction products such as prostanoids and superoxide radicals. Additionally, NS-398 is shown to reduce the extent of neuronal damage caused by glutamate excitotoxicity and by N-methyl-D-aspartate injection through blocking the Cox-2 response. Another report assessing Cox-2-mediated neuronal damage associated with methamphetamine further indicates that reactive oxygen species generated by Cox-2 are culprit in this process, rather than prostaglandin expression strongly associated with Cox enzymes and the inflammatory response.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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