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PD 0325901 (CAS: 391210-10-9)
Catalog #£ºEBC51043
  SKU-Pack Size Availability Size Price
EBC51043-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51043-5MG In Stock 5mg €63.70
EBC51043-10MG In Stock 10mg €102.70
EBC51043-25MG In Stock 25mg €180.70
EBC51043-50MG In Stock 50mg €271.70
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Product Information
Synonym(s) PD-0325901, Mirdametinib
Chemical Name N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Application PD0325901 is a specific and non-ATP-competitive MEK inhibitor
CAS Number 391210-10-9
Purity ¡Ý99.0%
Molecular Weight 482.19
Molecular Formula C16H14F3In2O4
SMILES C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
Target & IC50 MEK: IC50 = 0.33nM
Solubility DMSO: 96 mg/mL (199.09 mM)<>Ethanol: 96 mg/mL (199.09 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.0739 ml 10.3693 ml 20.7386 ml
5 mM 0.4148 ml 2.0739 ml 4.1477 ml
10 mM 0.2074 ml 1.0369 ml 2.0739 ml
50 mM 0.0415 ml 0.2074 ml 0.4148 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

PD 0325901 is a potent and selective MEK1 and MEK2 inhibitor. It is reported to inhibit cell proliferation and arrest cell cycle at the G0/G1 phase of thyroid cancer cells. PD 0325901 can be used with CHIR99021 to reprogram somatic cells into iPS cells and promote cell self-renewal. Studies have shown that in comparison to the CI-1040 MEK inhibitor that PD 0325901 has a greater potency of inhibition, longer duration, greater solubility, improved bioavailability, and increased metabolic stability. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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