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U0126-EtOH (CAS: 1173097-76-1)
Catalog #£ºEBC51041
  SKU-Pack Size Availability Size Price
EBC51041-1ML In Stock 1mL(10mM in DMSO) €76.70
EBC51041-5MG In Stock 5mg €63.70
EBC51041-10MG In Stock 10mg €102.70
EBC51041-25MG In Stock 25mg €180.70
EBC51041-50MG In Stock 50mg €258.70
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Product Information
Synonym(s) U-0126 Ethanol, U0126 Ethanol
Chemical Name (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol
Application U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2
CAS Number 1173097-76-1
Purity ¡Ý99.0%
Molecular Weight 426.56
Molecular Formula C₂₀H₂₂N₆OS₂
SMILES NC1=CC=CC=C1S/C(N)=C(/C(C#N)=C(SC2=C(C=CC=C2)N)\N)C#N.CCO
Target & IC50 MEK1: IC50 = 70 nM
MEK2: IC50 = 60 nM
Solubility DMSO: 79 mg/mL (185.2 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.6282 ml 13.1409 ml 26.2819 ml
5 mM 0.5256 ml 2.6282 ml 5.2564 ml
10 mM 0.2628 ml 1.3141 ml 2.6282 ml
50 mM 0.0526 ml 0.2628 ml 0.5256 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

U0126 was screened out as an anti-inflammatory agent that inhibited AP-1 transcription with IC50 value of 1μM and had no interactions with GREs. U0126 binds MEK1/2 in a unique site. This inhibition of MEK1/2 is noncompetitive with ERK and ATP. U0126 showed no effects on other MAPKKs. In HT22 cells, U0126 treatment significantly inhibited the cell injury caused by oxidative glutamate toxicity and remarkably blocked the phosphorylation of ERK1/2. Besides that, U0126 exerted no neuroprotection against other stimuli such as TNFα and actinomycin D. U0126 treatment also protected the primary cultured cortical neurons from oxidative glutamate toxicity and hypoxia/reoxygenation. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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