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EX 527 (CAS: 49843-98-3)
Catalog #£ºEBC51040
  SKU-Pack Size Availability Size Price
EBC51040-1ML In Stock 1mL(10mM in DMSO) €63.70 / €44.59
EBC51040-5MG In Stock 5mg €63.70 / €44.59
EBC51040-10MG In Stock 10mg €89.70 / €62.79
EBC51040-25MG In Stock 25mg €141.70 / €99.19
EBC51040-50MG In Stock 50mg €219.70 / €153.79
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Product Information
Synonym(s) EX-527, SEN0014196, Selisistat
Chemical Name 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Application EX 527 is a potent inhibitor of the SIRT1 class III histone deacetylase enzyme, selective over SIRT2 and SIRT3.
CAS Number 49843-98-3
Purity ¡Ý98.0%
Molecular Weight 248.71
Molecular Formula C₁₃H₁₃ClN₂O
SMILES O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Target & IC50 SIRT1: IC50 = 98 nM
SIRT2: IC50 = 19.6 ¦ÌM
SIRT3: IC50 = 48.7 ¦ÌM
Solubility DMSO: 49 mg/mL (197.02 mM)
Ethanol: 30 mg/mL (120.62 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.0211 ml 20.1037 ml 40.2075 ml
5 mM 0.8042 ml 4.0207 ml 8.0415 ml
10 mM 0.4021 ml 2.0104 ml 4.0208 ml
50 mM 0.0804 ml 0.4021 ml 0.8042 ml
Shipping Gel Pack
Storage Store at 4¡ã C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Selisistat (EX-527) is an inhibitor of SIRT1 enzymatic activity (IC50, 98 nM), identified in a high-throughput screen using bacterially expressed human SIRT1. Selisistat (EX-527) inhibits SIRT1 in a concentration-dependent manner with an IC50 of 38 nM, in agreement with the activity on bacterially expressed SIRT1. Selisistat (EX-527) has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM) but does not inhibit class I/II HDAC activity at concentrations up to 100 μM. Selisistat (EX-527) exerts an inhibitory effect on SIRT1 activity without affecting SIRT1 expression on both mRNA and protein levels.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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