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Apremilast (CAS: 608141-41-9)
Catalog #:EBC51039
  SKU-Pack Size Availability Size Price
EBC51037-1ML In Stock 1mL(10mM in DMSO) $178.50
EBC51039-2MG In Stock 5mg $111.00
EBC51039-10MG In Stock 10mg $178.50
EBC51039-25MG In Stock 25mg $298.50
EBC51039-50MG In Stock 50mg $403.50
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Product Information
Synonym(s) CC-10004, CC 10004, CC10004
Chemical Name (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Application Apremilast is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
CAS Number 608141-41-9
Purity ≥99.0%
Molecular Weight 460.5
Molecular Formula C22H24N2O7S
SMILES C(=O)1C2=C(C(NC(C)=O)=CC=C2)C(=O)N1[C@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O
Target & IC50 PDE4: IC50 = 74 nM
TNF-α: IC50 = 77 nM
Solubility DMSO: 92 mg/mL (199.78 mM)(br) Ethanol: 3 mg/mL (6.51 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1716 ml 10.8578 ml 21.7155 ml
5 mM 0.4343 ml 2.1716 ml 4.3431 ml
10 mM 0.2172 ml 1.0858 ml 2.1716 ml
50 mM 0.0434 ml 0.2172 ml 0.4343 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Apremilast is more potent For inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 product

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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