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IBMX (CAS: 28822-58-4)
Catalog #:EBC51868
  SKU-Pack Size Availability Size Price
EBC51868-1ML In Stock 1mL(10mM in DMSO) £59.40 / £41.58
EBC51868-50MG In Stock 50mg £59.40 / £41.58
EBC51868-100MG In Stock 100mg £70.40 / £49.28
EBC51868-250MG In Stock 250mg £125.40 / £87.78
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Product Information
Synonym(s) Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine
Chemical Name 1-Methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
Application IBMX is a potent and nonspecific inhibitor of PDE (phosphodiesterases) and can increase intracellular cyclic AMP levels
CAS Number 28822-58-4
Purity ≥99.0%
Molecular Weight 222.24
Molecular Formula C₁₀H₁₄N₄O₂
SMILES O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O
Target & IC50 PDE3: IC50 = 18 μM
PDE4: IC50 = 13 μM
PDE1: IC50 = 19 μM
PDE5 : IC50 = 32 μM
Solubility DMSO: 44 mg/mL (197.98 mM)
Ethanol: 7 mg/mL (31.50 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.4996 ml 22.4982 ml 44.9964 ml
5 mM 0.8999 ml 4.4996 ml 8.9993 ml
10 mM 0.4500 ml 2.2498 ml 4.4996 ml
50 mM 0.0900 ml 0.4500 ml 0.8999 ml
Shipping Room Temperature
Storage Room Temperature
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

IBMX is one of the most potent and nonspecific inhibitors of cyclic nucleotide PDE (phosphodiesterases) with documented IC50 values for PDE1, 2, 3, 4, and 5 equaling 19, 50, 18, 13 and 32. IBMX is documented to raise intracellular cyclic AMP levels. In rat sensory neurons the addition of IBMX caused the release of Ca2+ from caffeine ryanodine sensitive internal stores increasing the internal Ca2+ levels and inducing a biphasic membrane current response. Through PDE inhibition IBMX has also inhibited TNFα. IBMX in breast cancer cells has also induced p21 and p27 through a PKA independent pathway. Although a nonspecific PDE inhibitor IBMX does not show inhibition of PDE8B.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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