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PF06840003 (CAS: 198474-05-4)
Catalog #:EBC51038
  SKU-Pack Size Availability Size Price
EBC51038-1ML In Stock 1mL(10mM in DMSO) £97.90
EBC51038-2MG In Stock 2mg £75.90
EBC51038-5MG In Stock 5mg £97.90
EBC51038-10MG In Stock 10mg £141.90
EBC51038-25MG In Stock 25mg £273.90
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Product Information
Synonym(s) PF-06840003, EOS200271
Chemical Name 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione
Application PF06840003 is a specific and oral active IDO-1 inhibitor
CAS Number 198474-05-4
Purity ≥99.0%
Molecular Weight 232.21
Molecular Formula C₁₂H₉FN₂O₂
SMILES O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O
Target & IC50 hIDO-1: IC50 = 0.41 μM
dIDO-1: IC50 = 0.59 μM
mIDO-1: IC50 = 1.5 μM
Solubility DMSO: 46 mg/mL (198.10 mM)
Ethanol: 6 mg/mL (25.84 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.3064 ml 21.5322 ml 43.0644 ml
5 mM 0.8613 ml 4.3064 ml 8.6129 ml
10 mM 0.4306 ml 2.1532 ml 4.3064 ml
50 mM 0.0861 ml 0.4306 ml 0.8613 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. Upon administration, IDO1 inhibitor PF-06840003 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, PF-06840003 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes; PF-06840003 also induces increased interferon (IFN) production, and causes a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1, a cytosolic enzyme responsible for tryptophan catabolism and the conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs); it plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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