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2-PMPA (CAS: 173039-10-6)
Catalog #:EBC51032
  SKU-Pack Size Availability Size Price
EBC51032-1MG In Stock 1mg £53.90
EBC51032-5MG In Stock 5mg £97.90
EBC51032-10MG In Stock 10mg £174.90
EBC51032-25MG In Stock 25mg £372.90
EBC51032-50MG In Stock 50mg £537.90
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Product Information
Synonym(s) NAALDase Inhibitor, PMPA
Chemical Name 2-(phosphonomethyl)pentanedioic acid
Application 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII)
CAS Number 173039-10-6
Purity ≥98.0%
Molecular Weight 226.12
Molecular Formula C₆H₁₁O₇P
SMILES C(CC(=O)O)C(CP(=O)(O)O)C(=O)O
Target & IC50 GCPII: IC50= 300 pM
Solubility H2O: 28 mg/mL (123.83 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 4.4224 ml 22.1120 ml 44.2241 ml
5 mM 0.8845 ml 4.4224 ml 8.8448 ml
10 mM 0.4422 ml 2.2112 ml 4.4224 ml
50 mM 0.0884 ml 0.4422 ml 0.8845 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. InVitro: 2-PMPA is a potent and selective inhibitor of GCPII, an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. 2-PMPA demonstrates robust efficacy in numerous animal models of neurological disease. 2-PMPA is a highly polar compound with multiple negative charges causing significant challenges for analysis in biological matrices. 2-PMPA reduces ketamine-induced decrease of cell viability and increase of LDH levels in the mixed cultures but not in the neuronal cultures.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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