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CCT196969 (CAS: 1163719-56-9)
Catalog #£ºEBC51026
  SKU-Pack Size Availability Size Price
EBC51026-5MG In Stock 5mg €76.70
EBC51026-10MG In Stock 10mg €128.70
EBC51026-50MG In Stock 50mg €557.70
EBC51026-100MG In Stock 100mg €908.70
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Product Information
Synonym(s) CCT196969; CCT-196969; CCT 196969
Chemical Name 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
Application CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity
CAS Number 1163719-56-9
Purity ¡Ý99.70%
Molecular Weight 513.52
Molecular Formula C27H24FN7O3
SMILES FC1=CC(OC2=C3C(NC(C=N3)=O)=NC=C2)=CC=C1NC(NC4=CC(C(C)(C)C)=NN4C5=CC=CC=C5)=O
Target & IC50 CRAF: IC50 = 0.01 ¦ÌM
LCK: IC50 = 0.02 ¦ÌM
Src: IC50 = 0.03 ¦ÌM
BRAF: IC50 = 0.1 ¦ÌM
Solubility DMSO: 100 mg/mL (194.73 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.9473 ml 9.7367 ml 19.4734 ml
5 mM 0.3895 ml 1.9473 ml 3.8947 ml
10 mM 0.1947 ml 0.9737 ml 1.9473 ml
50 mM 0.0389 ml 0.1947 ml 0.3895 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT196969 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK–ERK, in vitro and in vivo. CCT196969 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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