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PD-173955 (CAS: 260415-63-2)
Catalog #:EBC51063
  SKU-Pack Size Availability Size Price
EBC51063-1ML In Stock 1mL(10mM in DMSO) $253.50
EBC51063-1MG In Stock 1mg $103.50
EBC51063-5MG In Stock 5mg $193.50
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Product Information
Synonym(s) PD 173955, PD173955
Chemical Name 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
Application PD173955 is a potent inhibitor of Bcr-Abl, Src and Yes
CAS Number 260415-63-2
Purity ≥99.0%
Molecular Weight 443.35
Molecular Formula C₂₁H₁₆Cl₂N₄OS
SMILES O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C
Target & IC50 Bcr-Abl: IC50 = 1nM-2nM
Src: IC50 = 22nM
Solubility DMSO: 12 mg/mL (27.1 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.2556 ml 11.2778 ml 22.5555 ml
5 mM 0.4511 ml 2.2556 ml 4.5111 ml
10 mM 0.2256 ml 1.1278 ml 2.2556 ml
50 mM 0.0451 ml 0.2256 ml 0.4511 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

PD173955 is a potent Bcr-Abl, Src and Yes inhibitor. When tested with CML CD34+ GM progenitors, PD173955 inhibited KL-dependent proliferation at an IC50 value of 50 nM and GM-CSF-dependent cell growth at an IC50 value of 1μM and the maximum inhibition was achieved at the dose of 25 nM. It was shown that PD173955 reduced the fractions of cells in G2-M phase and increased the cells in G1 phase with significant difference . In HT29 cells, PD173955 treatment inhibited Src auot-phosphorylation in a dose dependent manner. Further, PD173955 showed inhibition on cell growth with IC50 value of 800 nM without morphologic changes and high concentrations arrested cell cycle at the M phase . When tested with Bcr-Abl-depedent cell lines K562 and RWLeu4, PD173955 showed inhibition on cell proliferation with the IC50 value of 35 and 10 nM, respectively and arrested cell cycle in G1 phase at the low nanomola

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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