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YM 155 (CAS: 781661-94-7)
Catalog #£ºEBC51023
  SKU-Pack Size Availability Size Price
EBC51023-1ML In Stock 1mL(10mM in DMSO) €76.70
EBC51023-5MG In Stock 5mg €63.70
EBC51023-10MG In Stock 10mg €102.70
EBC51023-25MG In Stock 25mg €232.70
EBC51023-100MG In Stock 100mg €518.70
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Product Information
Synonym(s) Sepantronium bromide, YM-155, YM155
Chemical Name 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
Application YM 155 is an inhibitor of survivin expression and apoptosis inducer
CAS Number 781661-94-7
Purity ¡Ý99.0%
Molecular Weight 443.26
Molecular Formula C₂₀H₁₉BrN₄O₃
SMILES CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
Target & IC50 Survivin: IC50 = 0.54nM
Solubility DMSO: 55 mg/mL (124.07 mM)
Ethanol: 6 mg/mL (13.53 mM)
Water: 89 mg/mL (200.77 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.2559 ml 11.2793 ml 22.5586 ml
5 mM 0.4512 ml 2.2559 ml 4.5117 ml
10 mM 0.2256 ml 1.1279 ml 2.2559 ml
50 mM 0.0451 ml 0.2256 ml 0.4512 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

YM155, is a novel small-molecule suppressant of surviving, the smallest member of inhibitor of apoptosis (IAP) gene family. It exhibits a potent suppressive activity against survivin but has little effect on expression levels of other IAP family members or B-cell lymphoma 2 (BCL-2) related proteins. YM155 also suppresses proliferation in a broad range of human cancer cell lines, induces tumor regression in non-small cell lung cancer (NSCLC), melanoma, bladder, aggressive non-Hodgkin lymphoma, and breast cancer xenograft models, reduces spontaneous metastases, and significantly prolongs the survival of animal harboring established metastatic tumors derived from a human triple-negative breast cancer (TNBC) cell lines.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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