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Trichostatin A (CAS: 58880-19-6)
Catalog #:EBC51120
  SKU-Pack Size Availability Size Price
EBC51120-1ML In Stock 1mL(10mM in DMSO) £207.90
EBC51120-2MG In Stock 1mg £64.90
EBC51120-5MG In Stock 5mg £196.90
EBC51120-10MG In Stock 10mg £306.90
EBC51120-25MG In Stock 25mg £614.90
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Product Information
Synonym(s) TSA
Chemical Name (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
Application Trichostatin A is a potent and non-competitive reversible inhibitor of HDAC
CAS Number 58880-19-6
Purity ≥99.0%
Molecular Weight 302.37
Molecular Formula C₁₇H₂₂N₂O₃
SMILES CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Target & IC50 HDAC1 : IC50 = 70 nM; IL-2 gene expression : IC50 = 73 nM
Solubility DMSO: 15.1 mg/mL (50 mM)
Ethanol: 3 mg/mL (10 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.3072 ml 16.5360 ml 33.0721 ml
5 mM 0.6614 ml 3.3072 ml 6.6144 ml
10 mM 0.3307 ml 1.6536 ml 3.3072 ml
50 mM 0.0661 ml 0.3307 ml 0.6614 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of HDAC (histone deacetylase) with a Ki of 3.4 nM. In HeLa cells, Trichostatin A blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin.Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Trichostatin A is also known as TSA, and [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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