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Pifithrin-α (CAS: 63208-82-2)
Catalog #:EBC51816
  SKU-Pack Size Availability Size Price
EBC51816-1ML In Stock 1mL(10mM in DMSO) $133.50
EBC51816-5MG In Stock 5mg $73.50
EBC51816-10MG In Stock 10mg $118.50
EBC51816-25MG In Stock 25mg $253.50
EBC51816-50MG In Stock 50mg $388.50
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Product Information
Synonym(s) PFT-α, PFTα hydrobromide, Pifithrin hydrobromide, Pifithrin-α
Chemical Name 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone
Application Pifithrin-α is an inhibitor of p53
CAS Number 63208-82-2
Purity ≥98.0%
Molecular Weight 367.30
Molecular Formula C₁₆H₁₉BrN₂OS
SMILES CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br
Target & IC50 P53
Solubility DMSO: 3.673 mg/mL (10 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.7226 ml 13.6129 ml 27.2257 ml
5 mM 0.5445 ml 2.7226 ml 5.4451 ml
10 mM 0.2723 ml 1.3613 ml 2.7226 ml
50 mM 0.0545 ml 0.2723 ml 0.5445 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Pifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. In MEF cells transformed with E1a+ras, 10μM Pifithrin-α can inhibit the apoptosis of the cells and this anti-apoptotic activity is p53-dependent. Pifithrin-α also inhibits the growth arrest of human diploid fibroblasts induced by DNA damage but has no effect on p53-deficient fibroblasts. In addition, Pifithrin-α induces G2-arrest of cells after gamma irradiation.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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