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Nutlin-3 (CAS: 548472-68-0)
Catalog #:EBC51021
  SKU-Pack Size Availability Size Price
EBC51021-1ML In Stock 1mL(10mM in DMSO) $193.50
EBC51021-2MG In Stock 2mg $103.50
EBC51021-5MG In Stock 5mg $133.50
EBC51021-10MG In Stock 10mg $208.50
EBC51021-50MG In Stock 50mg $583.50
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Product Information
Synonym(s) Nutlin3, p53/MDM2 Agonist
Chemical Name 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
Application Nutlin-3 is an apoptosis inducer and disruptor of MDM2-p53
CAS Number 548472-68-0
Purity ≥99.0%
Molecular Weight 581.49
Molecular Formula C₃₀H₃₀Cl₂N₄O₄
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Target & IC50 p53/MDM2 interaction: IC50 = 0.09 μM; 1043SK: IC50 = 2.2 μM (human); NIH/3T3: IC50 = 1.3 μM (mouse)
Solubility DMSO:100 mg/mL (171.97 mM)
Ethanol:100 mg/mL (171.97 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.7197 ml 8.5986 ml 17.1972 ml
5 mM 0.3439 ml 1.7197 ml 3.4394 ml
10 mM 0.1720 ml 0.8599 ml 1.7197 ml
50 mM 0.0344 ml 0.1720 ml 0.3439 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Nutlin-3 is an inhibitor of the MDM2-p53 interaction. In particular, co-treatment of p53-positive HCT116 cells with 1 μM of Inauhzin and 2 μM of Nutlin-3 more significantly activated p53 as measured by its protein level as well as the level of its target p21, PUMA or cleaved PARP as indication of apoptosis

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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