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Axitinib (CAS: 319460-85-0)
Catalog #£ºEBC51020
  SKU-Pack Size Availability Size Price
EBC51020-1ML In Stock 1mL(10mM in DMSO) €76.70
EBC51020-25MG In Stock 25mg €63.70
EBC51020-50MG In Stock 50mg €76.70
EBC51020-100MG In Stock 100mg €115.70
EBC51020-200MG In Stock 200mg €206.70
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Product Information
Synonym(s) AG 013736
Chemical Name N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
Application Axitinib is a selective inhibitor of VEGFR, PDGFR, and c-kit tyrosine kinases.
CAS Number 319460-85-0
Purity ¡Ý99.0%
Molecular Weight 386.47
Molecular Formula C22H18N4OS
SMILES CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
Target & IC50 PDGF-¦Á: IC50 = 5.0 nM
PDGF-¦Â: IC50 = 1.6 nM
VEGFR1/FLT1: IC50 = 0.1 nM
Solubility DMSO: 26 mg/mL (67.28 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5875 ml 12.9376 ml 25.8752 ml
5 mM 0.5175 ml 2.5875 ml 5.1750 ml
10 mM 0.2588 ml 1.2938 ml 2.5875 ml
50 mM 0.0518 ml 0.2588 ml 0.5175 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Axitinib is a selective inhibitor of VEGFR, PDGFR, and c-kit tyrosine kinases. Axitinib inhibited the phosphorylation of VEGFR-1, 2 and 3 with IC50 values of 1.2 nM, 0.2 nM and 0.1 to 0.3 nM in cells, respectively. In HUVEC cells, Axitinib inhibited VEGFR-2 stimulated cell survival with about 1000-fold selectivity against FGFR-1. Axitinib also significantly suppressed the phosphorylation of VEGF downstream signaling molecules including Akt, eNOS and ERK1/2. Besides that, axitinib inhibited VEGFR-2 phosphorylation with EC50 value of 0.49 nM in vivo. It delayed tumore growth of human xenograft tumors in mice such as M24met, HCT-116 and SN12C.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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