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17-AAG (CAS: 75747-14-7)
Catalog #:EBC51010
  SKU-Pack Size Availability Size Price
EBC51010-1ML In Stock 1mL(10mM in DMSO) $103.50 / $72.45
EBC51010-10MG In Stock 10mg $103.50 / $72.45
EBC51010-50MG In Stock 50mg $253.50 / $177.45
EBC51010-100MG In Stock 100mg $358.50 / $250.95
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Product Information
Synonym(s) Tanespimycin
Chemical Name 17-Demethoxy-17-(2-propenylamino)-geldanamycin
Application 17-AAG is a potent heat shot protein 90 Hsp90) inhibitor for BT474 tumor cells, derived from geldanamycin.
CAS Number 75747-14-7
Purity ≥99.0%
Molecular Weight 585.69
Molecular Formula C₃₁H₄₃N₃O₈
SMILES O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C
Target & IC50 Hsp90: = 5 μM
Solubility DMSO: 58.0 mg/mL (100 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.7074 ml 8.5369 ml 17.0739 ml
5 mM 0.3415 ml 1.7074 ml 3.4148 ml
10 mM 0.1707 ml 0.8537 ml 1.7074 ml
50 mM 0.0341 ml 0.1707 ml 0.3415 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

17-AAG is a less toxic and more stable analog of geldanamycin. 17-AAG is an Hsp90 inhibitor that displays a 100-fold higher affinity for Hsp90 derived from tumor cells compared to Hsp90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of anti tumor agents such as taxol2, cisplatin3, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α5. In the prostate, 17-AAG can inhibit the growth of cancer cell lines.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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