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RepSox (CAS: 446859-33-2)
Catalog #£ºEBC51009
  SKU-Pack Size Availability Size Price
EBC51009-1ML In Stock 1mL(10mM in DMSO) €63.70
EBC51009-5MG In Stock 5mg €102.70
EBC51009-10MG In Stock 10mg €128.70
EBC51009-25MG In Stock 25mg €206.70
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Product Information
Synonym(s) Ladakamycin, NSC 102816, Vidaza
Chemical Name 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Application RepSox is an ATP-competitive inhibitor of TGF-¦Â RI kinase
CAS Number 446859-33-2
Purity ¡Ý98.0%
Molecular Weight 287.32
Molecular Formula C₁₇H₁₃N₅
SMILES CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
Target & IC50 Autophosphorylation of TGF-¦Â RI kinase: IC50 = 4 nM
ellular assay of TGF ¦Â RI kinase: IC50 = 18 nM
Solubility DMSO: 53 mg/mL (184.5 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.4804 ml 17.4022 ml 34.8044 ml
5 mM 0.6961 ml 3.4804 ml 6.9609 ml
10 mM 0.3480 ml 1.7402 ml 3.4804 ml
50 mM 0.0696 ml 0.3480 ml 0.6961 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Product Description

RepSox is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM), minimally. ALK5 Inhibitor II has also been used as a basal media component for culturing human Pluripotent stem cells.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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