USA£º(540) 808-3925
China£º400-117-0038
Ireland
Shopping Cart
Sign in \ Register
MG-132 (CAS: 133407-82-6)
Catalog #£ºEBC51001
  SKU-Pack Size Availability Size Price
EBC51001-1ML In Stock 1mL(10mM in DMSO) €50.70 / €35.49
EBC51001-5MG In Stock 5mg €50.70 / €35.49
EBC51001-10MG In Stock 10mg €63.70 / €44.59
EBC51001-25MG In Stock 25mg €141.70 / €99.19
EBC51001-50MG In Stock 50mg €206.70 / €144.69
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
Cambiotech Phone£º+44 (0) 188 448801
Lanwades Business Park, E-mail£ºinfo@cambiotech.com
Ireland Kobenhavn K, Ireland Web£ºwww.cambiotech.com
Product Information
Synonym(s) MG132, MG 132, Z-LLL-al, Z-Leu-Leu-Leu-CHO
Chemical Name N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Application MG-132 is a potent cell-permeable 20S proteasome inhibitor
CAS Number 133407-82-6
Purity ¡Ý98.0%
Molecular Weight 475.62
Molecular Formula C₂₆H₄₁N₃O₅
SMILES O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C
Target & IC50 NF-¦ÊB: IC50 = 3 ¦ÌM
Suc-LLVY-AMC: IC50 = 0.85 ¦ÌM
Z-LLL-AMC: IC50 = 0.1 ¦ÌM
I¦ÊB¦Á: IC50 = 3 ¦ÌM
Solubility DMSO: 93 mg/mL (139.1 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1025 ml 10.5126 ml 21.0252 ml
5 mM 0.4205 ml 2.1025 ml 4.2050 ml
10 mM 0.2103 ml 1.0513 ml 2.1025 ml
50 mM 0.0421 ml 0.2103 ml 0.4205 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Product Description

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activato MG-132 also induces apoptosis

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
Create Citation

1, Braun HA, et al. Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines. J Biol Chem. 2005 Aug 5;280(31):28394-401.

For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved. ¡¡±¸°¸ºÅ£º½òICP±¸2022005142ºÅ-1