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Lipoxin A4 (CAS: 89663-86-5)
Catalog #:EBC51136
  SKU-Pack Size Availability Size Price
EBC51136-25UG In Stock 25ug $418.50
EBC51136-50UG In Stock 50ug $793.50
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Product Information
Synonym(s) LXA4
Chemical Name 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
Application Lipoxin A4 is a trihydroxy fatty acid produced through 15-HETE metabolism
CAS Number 89663-86-5
Purity ≥95.0%
Molecular Weight 352.46
Molecular Formula C₂₀H₃₂O₅
SMILES CCCCCC(/C=C/C=C/C=C/C=C/C(C(CCCC(=O)O)O)O)O
Solubility DMSO: 50 mg/ml
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.8372 ml 14.1860 ml 28.3720 ml
5 mM 0.5674 ml 2.8372 ml 5.6744 ml
10 mM 0.2837 ml 1.4186 ml 2.8372 ml
50 mM 0.0567 ml 0.2837 ml 0.5674 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Lipoxin A4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. Lipoxin A4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM. Lipoxin A4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition (potent human PKC (protein kinase C) activator; inhibits cytotoxicity of natural killer cells), and monocyte migration and adhesion. Biosynthesis occurs in human leukocytes and rat alveolar macrophages. Transcellular biosynthesis occurs via interaction of human neutrophils or granulocytes and platelets. Produced in human nasal polyps and bronchial tissue. Stimulates vasodilation and antagonizes LTD4-induced vasoconstriction. Induces glomerular hyperperfusion and hyperfiltration. Inhibits LTB4- or FMLP-induced leukocyte chemotaxis and blocks the mobilization of Ca2+ and IP3. Inhibits LTB4-induced inflammation in the hamster cheek pouch. Activates protein kinase C13. Regulates human myelopoiesis. Lipoxin A4 is an activator of GPR. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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