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CUR 61414 (CAS: 334998-36-6)
Catalog #£ºEBC51079
  SKU-Pack Size Availability Size Price
EBC51079-5MG In Stock 5mg €219.70
EBC51079-10MG In Stock 10mg €414.70
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Product Information
Synonym(s) CUR 61414, CUR61414, G-024586, Hedgehog signaling pathway antagonist
Chemical Name N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Application CUR 61414 is a mediator of hedgehog signaling pathways
CAS Number 334998-36-6
Purity ¡Ý98.0%
Molecular Weight 550.69
Molecular Formula C₃₁H₄₂N₄O₅
SMILES CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)[C@H]2C[C@H](N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5
Target & IC50 Hedgehog inhibitor
Solubility DMSO: 2 mg/mL (clear solution warmed)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.8159 ml 9.0795 ml 18.1590 ml
5 mM 0.3632 ml 1.8159 ml 3.6318 ml
10 mM 0.1816 ml 0.9080 ml 1.8159 ml
50 mM 0.0363 ml 0.1816 ml 0.3632 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

CUR-61414 is a smoothened receptor antagonist potentially for the treatment of basal cell carcinoma. CUR61414 significantly inhibited skin Hedgehog signaling, blocked the induction of hair follicle anagen, and shrank existing basal cell carcinomas. CUR61414 can suppress proliferation and induce apoptosis of basaloid nests in the basal cell carcinoma model systems, whereas having no effect on normal skin cells. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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