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AM 580 (CAS: 102121-60-8)
Catalog #:EBC51060
  SKU-Pack Size Availability Size Price
EBC51060-1ML In Stock 1mL(10mM in DMSO) $118.50
EBC51060-2MG In Stock 2mg $73.50
EBC51060-5MG In Stock 5mg $103.50
EBC51060-10MG In Stock 10mg $148.50
EBC51060-50MG In Stock 50mg $493.50
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Product Information
Synonym(s) CD336, NSC608001, Ro 40-6055
Chemical Name 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid
Application AM 580 is a retinoic acid analog and selective RARα agonist
CAS Number 102121-60-8
Purity ≥98.0%
Molecular Weight 351.44
Molecular Formula C₂₂H₂₅NO₃
SMILES O=C(O)c1ccc(cc1)NC(=O)c2ccc3c(c2)C(C)(C)CCC3(C)C
Target & IC50 RARα: IC50 = 41 nM
RARβ: EC5050 = 8.6 nM
Solubility DMSO: 45 mg/mL (128.04 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.8454 ml 14.2272 ml 28.4544 ml
5 mM 0.5691 ml 2.8454 ml 5.6909 ml
10 mM 0.2845 ml 1.4227 ml 2.8454 ml
50 mM 0.0569 ml 0.2845 ml 0.5691 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

AM 580 is a selective retinoic acid analog, which is useful in vitro as a RARα agonist. Studies indicate that RARα increases the signaling of the RARα receptor to prevent intracellular and extracellular amyloid-β accumulation. In addition, this receptor increases the expression of disintegrin and metalloprotease. Since amyloid-β accumulation is a major finding in Alzheimer's disease (AD), AM 580 can be used to study this disease in vitro. AM 580 also induces the functions of IL-4, IL-5 and IL-13 and suppresses the production of IL-12 and IFNγ. Alternate studies suggest that AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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